Structure of PDB 3ksa Chain C

Receptor sequence
>3ksaC (length=220) Species: 1313 (Streptococcus pneumoniae) [Search protein sequence]
KLTPAQSKNPAKNELYLVEGDSAGGSAKQGRDRKFQAILPLRGKVINTAK
AKMADILKNEEINTMIYTIGAGVDFSIEANYDKIIIMTDADTDGAHIQTL
LLTFFYRYMRPLVEAGHVYIALPPLYKMSKKKEEVAYAWTDGELEELRKQ
FGKGATLQRYKGLGEMNADQLWETTMNPETRTLIRVTIEDLARAERRVNV
LMGDKVEPRRKWIEDNVKFT
3D structure
PDB3ksa Structural Basis of Gate-DNA Breakage and Resealing by Type II Topoisomerases
ChainC
Resolution3.3 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 5.6.2.2: DNA topoisomerase (ATP-hydrolyzing).
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna C E433 K458 D510 E19 K44 D93
BS02 dna C K458 N461 K464 H513 V626 R629 K44 N47 K50 H96 V206 R209
BS03 dna C E433 D435 S436 G457 E19 D21 S22 G43
BS04 MG C E433 D506 E19 D89
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003918 DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity
GO:0005524 ATP binding
Biological Process
GO:0006265 DNA topological change

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Molecular Function
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Biological Process
External links
PDB RCSB:3ksa, PDBe:3ksa, PDBj:3ksa
PDBsum3ksa
PubMed20596531
UniProtQ59961|PARE_STRPN DNA topoisomerase 4 subunit B (Gene Name=parE)

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