Structure of PDB 3krd Chain C

Receptor sequence
>3krdC (length=222) Species: 1773 (Mycobacterium tuberculosis) [Search protein sequence]
TTIVALKYPGGVVMAGDRRSTQGNMISGRDVRKVYITDDYTATGIAGTAA
VAVEFARLYAVELEHYEKLEGVPLTFAGKINRLAIMVRGNLAAAMQGLLA
LPLLAGYDIHASDPQSAGRIVSFDAAGGWNIEEEGYQAVGSGSLFAKSSM
KKLYSQVTDGDSGLRVAVEALYDAADDDSATGGPDLVRGIFPTAVIIDAD
GAVDVPESRIAELARAIIESRS
3D structure
PDB3krd Fellutamide B is a potent inhibitor of the Mycobacterium tuberculosis proteasome.
ChainC
Resolution2.5 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.4.25.1: proteasome endopeptidase complex.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 FEB C T301 S320 T321 Q322 S327 G347 T348 A349 T1 S20 T21 Q22 S27 G47 T48 A49 PDBbind-CN: -logKd/Ki=8.17,Ki=6.8nM
BS02 FEB C D424 A425 D124 A125 PDBbind-CN: -logKd/Ki=8.17,Ki=6.8nM
Gene Ontology
Molecular Function
GO:0004298 threonine-type endopeptidase activity
Biological Process
GO:0010498 proteasomal protein catabolic process
GO:0051603 proteolysis involved in protein catabolic process
Cellular Component
GO:0005839 proteasome core complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:3krd, PDBe:3krd, PDBj:3krd
PDBsum3krd
PubMed20558127
UniProtP9WHT9|PSB_MYCTU Proteasome subunit beta (Gene Name=prcB)

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