Structure of PDB 3kr8 Chain C

Receptor sequence
>3kr8C (length=208) Species: 9606 (Homo sapiens) [Search protein sequence]
GTILIDLSPDDKEFQSVEEEMQSTVREHRDGGHAGGIFNRYNILKIQKVC
NKKLWERYTHRRKEVSEENHNHANERMLFHGSPFVNAIIHKGFDERHAYI
GGMFGAGIYFAENSSKSNQYVYGIGGGTGCPVHKDRSCYICHRQLLFCRV
TLGKSFLQFSAMAHSPPGHHSVTGRPSVNGLALAEYVIYRGEQAYPEYLI
TYQIMRPE
3D structure
PDB3kr8 Structural basis for the interaction between tankyrase-2 and a potent Wnt-signaling inhibitor.
ChainC
Resolution2.1 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.4.2.-
2.4.2.30: NAD(+) ADP-ribosyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN C C1081 H1084 C1089 C1092 C130 H133 C138 C141
BS02 XAV C H1031 G1032 F1035 A1049 Y1050 Y1060 F1061 A1062 S1068 Y1071 I1075 E1138 H80 G81 F84 A98 Y99 Y109 F110 A111 S117 Y120 I124 E185 MOAD: Kd=8nM
BindingDB: IC50=4nM,Kd=10nM
Gene Ontology
Molecular Function
GO:0003950 NAD+-protein poly-ADP-ribosyltransferase activity

View graph for
Molecular Function
External links
PDB RCSB:3kr8, PDBe:3kr8, PDBj:3kr8
PDBsum3kr8
PubMed20565110
UniProtQ9H2K2|TNKS2_HUMAN Poly [ADP-ribose] polymerase tankyrase-2 (Gene Name=TNKS2)

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