Structure of PDB 3kq4 Chain C

Receptor sequence
>3kq4C (length=385) Species: 9606 (Homo sapiens) [Search protein sequence]
SCSVPSAQEPLVNGIQVLMENSVTSSAYPNPSILIAMNLAGAYNLKAQKL
LTYQLMSSDNNDLTIGHLGLTIMALTSSCRDPGDKVSILQRQMENWAPSS
PNAEASAFYGPSLAILALCQKNSEATLPIAVRFAKTLLANSSPFNVDTGA
MATLALTCMYNKIPVGSEEGYRSLFGQVLKDIVEKISMKIKDNGIIGDIY
STGLAMQALSVTPEPSKKEWNCKKTTDMILNEIKQGKFHNPMSIAQILPS
LKGKTYLDVPQVTCSPDHEVQPTLPSASNITVIYTINNQLRGVELLFNET
INVSVKSGSVLLVVLEEAQRKNPMFKFETTMTSWGLVVSSINNIAENVNH
KTYWQFLSGVTPLNEGVADYIPFNHEHITANFTQY
3D structure
PDB3kq4 Structural basis for receptor recognition of vitamin-B(12)-intrinsic factor complexes.
ChainC
Resolution3.3 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 B12 C G90 H91 S130 Y133 D171 Y224 S225 S365 W366 G367 V369 V370 W386 F388 L395 N396 E397 G398 Y417 G66 H67 S106 Y109 D147 Y200 S201 S333 W334 G335 V337 V338 W354 F356 L363 N364 E365 G366 Y385
Gene Ontology
Molecular Function
GO:0005515 protein binding
GO:0031419 cobalamin binding
GO:0140355 cargo receptor ligand activity
Biological Process
GO:0006824 cobalt ion transport
GO:0015889 cobalamin transport
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005768 endosome
GO:0005902 microvillus
GO:0016324 apical plasma membrane
GO:0043202 lysosomal lumen

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:3kq4, PDBe:3kq4, PDBj:3kq4
PDBsum3kq4
PubMed20237569
UniProtP27352|IF_HUMAN Cobalamin binding intrinsic factor (Gene Name=CBLIF)

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