Structure of PDB 3khj Chain C

Receptor sequence
>3khjC (length=306) Species: 353152 (Cryptosporidium parvum Iowa II) [Search protein sequence]
TKNIGKGLTFEDILLVPNYSEVLPREVSLETKLTKNVSLKIPLISSAMDT
VTEHLMAVGMARLGGIGIIHKNMDMESQVNEVLKVKNSGGLRVGAAIGVN
EIERAKLLVEAGVDVIVLDSAHGHSLNIIRTLKEIKSKMNIDVIVGNVVT
EEATKELIENGADGIKVGIGPGSICTTRIVAGVGVPQITAIEKCSSVASK
FGIPIIADGGIRYSGDIGKALAVGASSVMIGSILAGTEESPGEKELIGDT
VYKYYRGIEGRVKYKGEMEGVVYQLVGGLRSCMGYLGSASIEELWKKSSY
VEITTS
3D structure
PDB3khj The structural basis of Cryptosporidium -specific IMP dehydrogenase inhibitor selectivity.
ChainC
Resolution2.8 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 1.1.1.205: IMP dehydrogenase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 IMP C S48 M50 G216 S217 C219 D252 G253 G275 S276 S46 M48 G172 S173 C175 D208 G209 G231 S232
BS02 C64 C G357 Y358 G284 Y285
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0003938 IMP dehydrogenase activity
GO:0016491 oxidoreductase activity
Biological Process
GO:0006164 purine nucleotide biosynthetic process

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Molecular Function
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Biological Process
External links
PDB RCSB:3khj, PDBe:3khj, PDBj:3khj
PDBsum3khj
PubMed20052976
UniProtQ5CPK7

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