Structure of PDB 3kdp Chain C

Receptor sequence
>3kdpC (length=998) Species: 9823 (Sus scrofa) [Search protein sequence]
AKKERDMDELKKEVSMDDHKLSLDELHRKYGTDLSRGLTPARAAEILARD
GPNALTPPPTTPEWVKFCRQLFGGFSMLLWIGAILCFLAYGIQAATEEEP
QNDNLYLGVVLSAVVIITGCFSYYQEAKSSKIMESFKNMVPQQALVIRNG
EKMSINAEEVVVGDLVEVKGGDRIPADLRIISANGCKVDNSSLTGESEPQ
TRSPDFTNENPLETRNIAFFSTNCVEGTARGIVVYTGDRTVMGRIATLAS
GLEGGQTPIAAEIEHFIHIITGVAVFLGVSFFILSLILEYTWLEAVIFLI
GIIVANVPEGLLATVTVCLTLTAKRMARKNCLVKNLEAVETLGSTSTICS
DKTGTLTQNRMTVAHMWSDNQIHEADTTENQSGVSFDKTSATWLALSRIA
GLCNRAVFQANQENLPILKRAVAGDASESALLKCIELCCGSVKEMRERYT
KIVEIPFNSTNKYQLSIHKNPNTAEPRHLLVMKGAPERILDRCSSILIHG
KEQPLDEELKDAFQNAYLELGGLGERVLGFCHLFLPDEQFPEGFQFDTDD
VNFPLDNLCFVGLISMIDPPRAAVPDAVGKCRSAGIKVIMVTGDHPITAK
AIAKGVGIISEGNETVEDIAARLNIPVSQVNPRDAKACVVHGSDLKDMTS
EQLDDILKYHTEIVFARTSPQQKLIIVEGCQRQGAIVAVTGDGVNDSPAS
KKADIGVAMGIAGSDVSKQAADMILLDDNFASIVTGVEEGRLIFDNLKKS
IAYTLTSNIPEITPFLIFIIANIPLPLGTVTILCIDLGTDMVPAISLAYE
QAESDIMKRQPRNPKTDKLVNEQLISMAYGQIGMIQALGGFFTYFVILAE
NGFLPIHLLGLRVNWDDRWINDVEDSYGQQWTYEQRKIVEFTCHTPFFVT
IVVVQWADLVICKTRRNSVFQQGMKNKILIFGLFEETALAAFLSYCPGMG
VALRMYPLKPTWWFCAFPYSLLIFVYDEVRKLIIRRRPGGWVEKETYY
3D structure
PDB3kdp Crystal structure of the sodium-potassium pump.
ChainC
Resolution3.5 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D710 D714
Catalytic site (residue number reindexed from 1) D692 D696
Enzyme Commision number 7.2.2.13: Na(+)/K(+)-exchanging ATPase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide C F949 F952 A956 Y963 P965 F931 F934 A938 Y945 P947
BS02 MF4 C D369 T371 T610 D351 T353 T592
BS03 MG C D369 T371 D710 D351 T353 D692
BS04 RB C S775 N776 E779 D804 S757 N758 E761 D786
BS05 RB C V325 E327 N776 D804 V307 E309 N758 D786
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0005215 transporter activity
GO:0005391 P-type sodium:potassium-exchanging transporter activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0008556 P-type potassium transmembrane transporter activity
GO:0016887 ATP hydrolysis activity
GO:0030955 potassium ion binding
GO:0031402 sodium ion binding
GO:0046872 metal ion binding
GO:0051117 ATPase binding
Biological Process
GO:0002028 regulation of sodium ion transport
GO:0006813 potassium ion transport
GO:0006814 sodium ion transport
GO:0006883 intracellular sodium ion homeostasis
GO:0010248 establishment or maintenance of transmembrane electrochemical gradient
GO:0030007 intracellular potassium ion homeostasis
GO:0036376 sodium ion export across plasma membrane
GO:0055085 transmembrane transport
GO:0086009 membrane repolarization
GO:1902600 proton transmembrane transport
GO:1990573 potassium ion import across plasma membrane
Cellular Component
GO:0005886 plasma membrane
GO:0005890 sodium:potassium-exchanging ATPase complex
GO:0016020 membrane
GO:0016323 basolateral plasma membrane
GO:0030424 axon
GO:0042383 sarcolemma
GO:0042470 melanosome
GO:0042995 cell projection

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:3kdp, PDBe:3kdp, PDBj:3kdp
PDBsum3kdp
PubMed18075585
UniProtP05024|AT1A1_PIG Sodium/potassium-transporting ATPase subunit alpha-1 (Gene Name=ATP1A1)

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