Structure of PDB 3kan Chain C

Receptor sequence
>3kanC (length=117) Species: 9606 (Homo sapiens) [Search protein sequence]
PFLELDTNLPANRVPAGLEKRLCAAAASILGKPADRVNVTVRPGLAMALS
GSTEPCAQLSISSIGVVGTAEDNRSHSAHFFEFLTKELALGQDRILIRFF
PLESWQIGKIGTVMTFL
3D structure
PDB3kan Targeting distinct tautomerase sites of D-DT and MIF with a single molecule for inhibition of neutrophil lung recruitment.
ChainC
Resolution1.13 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 4.1.1.84: D-dopachrome decarboxylase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 RW1 C P1 F2 R36 N38 P1 F2 R36 N38
Gene Ontology
Molecular Function
GO:0004167 dopachrome isomerase activity
GO:0005126 cytokine receptor binding
GO:0016829 lyase activity
GO:0033981 D-dopachrome decarboxylase activity
GO:0050178 phenylpyruvate tautomerase activity
Biological Process
GO:0010760 negative regulation of macrophage chemotaxis
GO:0032760 positive regulation of tumor necrosis factor production
GO:0042438 melanin biosynthetic process
GO:0050729 positive regulation of inflammatory response
GO:0070374 positive regulation of ERK1 and ERK2 cascade
Cellular Component
GO:0005615 extracellular space
GO:0005737 cytoplasm
GO:0070062 extracellular exosome

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:3kan, PDBe:3kan, PDBj:3kan
PDBsum3kan
PubMed25016026
UniProtP30046|DOPD_HUMAN D-dopachrome decarboxylase (Gene Name=DDT)

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