Structure of PDB 3k23 Chain C

Receptor sequence
>3k23C (length=246) Species: 9606 (Homo sapiens) [Search protein sequence]
LPQLTPTLVSLLEVIEPEVLYAGYDSSVPDSTWRIMTTLNMLGGRQVIAA
VKWAKAIPGFRNLHLDDQMTLLQYSWMYLMAFALGWRSYRQSSANLLCFA
PDLIINEQRMTLPGMYDQCKHMLYVSSELHRLQVSYEEYLCMKTLLLLSS
VPKDGLKQELFDEIRMTYIKELGKAIVKREGNSSQNWQRFYQLTKLLDSM
HEVVENLLNYCFQTFLDKTMIEFPEMLAEIITNQIPKYNIKKLLFH
3D structure
PDB3k23 Design and x-ray crystal structures of high-potency nonsteroidal glucocorticoid agonists exploiting a novel binding site on the receptor.
ChainC
Resolution3.0 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide C K579 M593 Q597 E751 M752 E755 N759 K55 M69 Q73 E225 M226 E229 N233
BS02 JZN C M560 L563 N564 L566 Q570 M604 A605 A607 L608 R611 F623 M646 L732 M36 L39 N40 L42 Q46 M80 A81 A83 L84 R87 F99 M122 L207 BindingDB: IC50=6.3nM
External links
PDB RCSB:3k23, PDBe:3k23, PDBj:3k23
PDBsum3k23
PubMed19822747
UniProtP04150|GCR_HUMAN Glucocorticoid receptor (Gene Name=NR3C1)

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