Structure of PDB 3iwy Chain C

Receptor sequence
>3iwyC (length=83) Species: 9606 (Homo sapiens) [Search protein sequence]
TLVRPKPLLLKLLKSVGAQKDTYTMKEVLFYLGQYIMTKRLYDEKQQHIV
YCSNDLLGDLFGVPSFSVKEHRKIYTMIYRNLV
3D structure
PDB3iwy D-peptide inhibitors of the p53-MDM2 interaction for targeted molecular therapy of malignant neoplasms.
ChainC
Resolution1.93 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.3.2.27: RING-type E3 ubiquitin transferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide C K94 E95 H96 R97 K69 E70 H71 R72
BS02 peptide C L54 F55 G58 Q59 I61 M62 Y67 Q72 V93 H96 Y100 L29 F30 G33 Q34 I36 M37 Y42 Q47 V68 H71 Y75
Gene Ontology
Biological Process
GO:0043066 negative regulation of apoptotic process
GO:0051726 regulation of cell cycle
Cellular Component
GO:0005634 nucleus

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Biological Process
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Cellular Component
External links
PDB RCSB:3iwy, PDBe:3iwy, PDBj:3iwy
PDBsum3iwy
PubMed20660730
UniProtQ00987|MDM2_HUMAN E3 ubiquitin-protein ligase Mdm2 (Gene Name=MDM2)

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