Structure of PDB 3iw4 Chain C

Receptor sequence
>3iw4C (length=334) Species: 9606 (Homo sapiens) [Search protein sequence]
NLDRVKLTDFNFLMVLGKGSFGKVMLADRKGTEELYAIKILKKDVVIQDD
DVECTMVEKRVLALLDKPPFLTQLHSCFQTVDRLYFVMEYVNGGDLMYHI
QQVGKFKEPQAVFYAAEISIGLFFLHKRGIIYRDLKLDNVMLDSEGHIKI
ADFGMCKEHMMDGVTTREFCGTPDYIAPEIIAYQPYGKSVDWWAYGVLLY
EMLAGQPPFDGEDEDELFQSIMEHNVSYPKSLSKEAVSICKGLMTKHPAK
RLGCGPEGERDVREHAFFRRIDWEKLENREIQPPFKPKVFDKFFTRGQPV
LTPPDQLVIANIDQSDFEGFSYVNPQFVHPILQS
3D structure
PDB3iw4 Discovery of 3-(1H-indol-3-yl)-4-[2-(4-methylpiperazin-1-yl)quinazolin-4-yl]pyrrole-2,5-dione (AEB071), a potent and selective inhibitor of protein kinase C isotypes
ChainC
Resolution2.8 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D463 K465 N468 D481 T501
Catalytic site (residue number reindexed from 1) D134 K136 N139 D152 T172
Enzyme Commision number 2.7.11.13: protein kinase C.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 LW4 C L345 G346 F350 V353 A366 T401 E418 Y419 V420 D467 M470 A480 D481 L16 G17 F21 V24 A37 T72 E89 Y90 V91 D138 M141 A151 D152 BindingDB: IC50=2.1nM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004697 diacylglycerol-dependent serine/threonine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:3iw4, PDBe:3iw4, PDBj:3iw4
PDBsum3iw4
PubMed19827831
UniProtP17252|KPCA_HUMAN Protein kinase C alpha type (Gene Name=PRKCA)

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