Structure of PDB 3ish Chain C

Receptor sequence
>3ishC (length=311) Species: 85962 (Helicobacter pylori 26695) [Search protein sequence]
MIDCAIIGGGPAGLSAGLYATRGGVKNAVLFEKGMPGGQITGSSEIENYP
GVKEVVSGLDFMQPWQEQCFRFGLKHEMTAVQRVSKKDSHFVILAEDGKT
FEAKSVIIATGGSPKRTGIKGESEYWGKGVSTCATCDGFFYKNKEVAVLG
GGDTAVEEAIYLANICKKVYLIHRRDGFRCAPITLEHAKNNDKIEFLTPY
VVEEIKGDASGVSSLSIKNTATNEKRELVVPGFFIFVGYDVNNAVLKQED
NSMLCKCDEYGSIVVDFSMKTNVQGLFAAGDIRIFAPKQVVCAASDGATA
ALSVISYLEHH
3D structure
PDB3ish Crystal structure of Helicobacter pylori thioredoxin reductase
ChainC
Resolution2.43 Å
3D
structure
Catalytic site residues are labeled in the structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Catalytic site (original residue number in PDB) C133 C136 D137
Catalytic site (residue number reindexed from 1) C133 C136 D137
Enzyme Commision number 1.8.1.9: thioredoxin-disulfide reductase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 FAD C G8 G10 P11 A12 E32 K33 G38 Q39 I40 I46 N48 A80 V81 T110 G111 C136 G280 D281 K288 Q289 V290 G8 G10 P11 A12 E32 K33 G38 Q39 I40 I46 N48 A80 V81 T110 G111 C136 G280 D281 K288 Q289 V290
Gene Ontology
Molecular Function
GO:0004791 thioredoxin-disulfide reductase (NADPH) activity
GO:0016491 oxidoreductase activity
Biological Process
GO:0019430 removal of superoxide radicals
GO:0045454 cell redox homeostasis
Cellular Component
GO:0005737 cytoplasm

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:3ish, PDBe:3ish, PDBj:3ish
PDBsum3ish
PubMed
UniProtP56431|TRXB_HELPY Thioredoxin reductase (Gene Name=trxB)

[Back to BioLiP]