Structure of PDB 3i08 Chain C

Receptor sequence
>3i08C (length=174) Species: 9606 (Homo sapiens) [Search protein sequence]
ACELPECQEDAGNKVCSLQCNNHACGWDGGDCSLNFNDPWKNCTQSLQCW
KYFSDGHCDSQCNSAGCLFDGFDCQRAEGQCNPLYDQYCKDHFSDGHCDQ
GCNSAECEWDGLDCAEHVPERLAAGTLVVVVLMPPEQLRNSSFHFLRELS
RVLHTNVVFKRDAHGQQMIFPYYG
3D structure
PDB3i08 Effects of S1 cleavage on the structure, surface export, and signaling activity of human Notch1 and Notch2.
ChainC
Resolution3.2 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CA C D1458 N1461 V1463 S1465 D1476 D1479 D10 N13 V15 S17 D28 D31
BS02 CA C Y1500 D1503 H1505 D1507 D1518 D1521 Y52 D55 H57 D59 D70 D73
BS03 CA C H1540 D1543 H1545 D1547 D1558 D1561 H92 D95 H97 D99 D110 D113
Gene Ontology
Biological Process
GO:0030154 cell differentiation
Cellular Component
GO:0016020 membrane

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Biological Process
View graph for
Cellular Component
External links
PDB RCSB:3i08, PDBe:3i08, PDBj:3i08
PDBsum3i08
PubMed19701457
UniProtP46531|NOTC1_HUMAN Neurogenic locus notch homolog protein 1 (Gene Name=NOTCH1)

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