Structure of PDB 3hkw Chain C

Receptor sequence
>3hkwC (length=560) [Search protein sequence]
SMSYSWTGALVTPCAAEEQKLPINALSNSLLRHHNMVYSTTSRSACQRQK
KVTFDRLQVLDSHYQDVLKEVKAAASKVKANLLSVEEACSLTPPHSARSK
FGYGAKDVRCHARKAVTHINSVWKDLLEDSVTPIDTTIMAKNEVFCVQGG
RKPARLIVFPDLGVRVCEKMALYDVVSKLPQAVMGSSYGFQYSPGQRVEF
LVQAWKSKKSPMGFSYDTRCFDSTVTESDIRTEEAIYQCCDLDPQARVAI
KSLTERLYVGGPLTNSKGENCGYRRCRASGVLTTSCGNTLTCYIKARAAC
RAAGLQDCTMLVCGDDLVVICESAGVQEDAASLRAFTEAMTRYSAPPGDP
PQPEYDLELITSCSSNVSVAHDGAGKRVYYLTRDPTTPLARAAWETARHT
PVNSWLGNIIMFAPTLWARMILMTHFFSVLIARDQLEQALDCEIYGACYS
IEPLDLPPIIQRLHGLSAFSLHSYSPGEINRVAACLRKLGVPPLRAWRHR
ARSVRAKLLSRGGRAAICGKYLFNWAVRTKLKLTPIAAAGQLDLSGWFTA
GYSGGDIYHS
3D structure
PDB3hkw 1a/1b subtype profiling of nonnucleoside polymerase inhibitors of hepatitis C virus
ChainC
Resolution1.55 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.7.48: RNA-directed RNA polymerase.
3.4.21.98: hepacivirin.
3.4.22.-
3.6.1.15: nucleoside-triphosphate phosphatase.
3.6.4.13: RNA helicase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 IX6 C R200 C366 S367 N411 M414 F415 Y448 S556 R197 C363 S364 N408 M411 F412 Y445 S553 MOAD: Kd=80nM
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003968 RNA-dependent RNA polymerase activity
Biological Process
GO:0039694 viral RNA genome replication

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Molecular Function
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Biological Process
External links
PDB RCSB:3hkw, PDBe:3hkw, PDBj:3hkw
PDBsum3hkw
PubMed20071590
UniProtP26664|POLG_HCV1 Genome polyprotein

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