Structure of PDB 3h6t Chain C

Receptor sequence
>3h6tC (length=261) Species: 10116 (Rattus norvegicus) [Search protein sequence]
NKTVVVTTILESPYVMMKKNHEMLEGNERYEGYCVDLAAEIAKHCGFKYK
LTIVGDGKYGARDADTKIWNGMVGELVYGKADIAIAPLTITLVREEVIDF
SKPFMSLGISIMIKKGTPIESAEDLSKQTEIAYGTLDSGSTKEFFRRSKI
AVFDKMWTYMRSAEPSVFVRTTAEGVARVRKSKGKYAYLLESTMNEYIEQ
RKPCDTMKVGGNLDSKGYGIATPKGSSLGNAVNLAVLKLSEQGLLDKLKN
KWWYDKGECGS
3D structure
PDB3h6t Distinct structural features of cyclothiazide are responsible for effects on peak current amplitude and desensitization kinetics at iGluR2.
ChainC
Resolution2.25 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CYZ C S217 K218 S215 K216 BindingDB: EC50=7600nM
BS02 GLU C Y61 L90 T91 R96 G141 S142 T143 E193 Y59 L88 T89 R94 G139 S140 T141 E191
BS03 CYZ C K104 P105 M107 S108 L239 S242 L247 D248 K102 P103 M105 S106 L237 S240 L245 D246 BindingDB: EC50=7600nM
BS04 ZN C E42 H46 E40 H44
Gene Ontology
Molecular Function
GO:0015276 ligand-gated monoatomic ion channel activity
Cellular Component
GO:0016020 membrane

View graph for
Molecular Function
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Cellular Component
External links
PDB RCSB:3h6t, PDBe:3h6t, PDBj:3h6t
PDBsum3h6t
PubMed19591837
UniProtP19491|GRIA2_RAT Glutamate receptor 2 (Gene Name=Gria2)

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