Structure of PDB 3h4v Chain C

Receptor sequence
>3h4vC (length=259) Species: 5664 (Leishmania major) [Search protein sequence]
VPVALVTGAAKRLGRSIAEGLHAEGYAVCLHYHRSAAEANALSATLNARR
PNSAITVQADLSNVATAPSAPVTLFTRCAELVAACYTHWGRCDVLVNNAS
SFYPTPLLRNDREAMETATADLFGSNAIAPYFLIKAFAHRVAGTPAKHRG
TNYSIINMVDAMTNQPLLGYTIYTMAKGALEGLTRSAALELAPLQIRVNG
VGPGLSVLVEGHRSKVPLYQRDSSAAEVSDVVIFLCSSKAKYITGTCVKV
DGGYSLTRA
3D structure
PDB3h4v Discovery of potent pteridine reductase inhibitors to guide antiparasite drug development
ChainC
Resolution2.4 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) R17 D181 Y194
Catalytic site (residue number reindexed from 1) R12 D160 Y173
Enzyme Commision number 1.5.1.33: pteridine reductase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 NAP C R17 L18 H36 Y37 H38 R39 S40 L66 N109 A110 S111 S112 M179 V180 D181 K198 P224 S227 R12 L13 H31 Y32 H33 R34 S35 L61 N98 A99 S100 S101 M158 V159 D160 K177 P203 S206
BS02 DVP C S111 F113 L188 Y194 H241 S100 F102 L167 Y173 H212 MOAD: Ki=0.1uM
BindingDB: Ki=100nM
Gene Ontology
Molecular Function
GO:0004155 6,7-dihydropteridine reductase activity
GO:0016491 oxidoreductase activity
GO:0047040 pteridine reductase activity
Biological Process
GO:0006729 tetrahydrobiopterin biosynthetic process
GO:0031427 response to methotrexate
Cellular Component
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:3h4v, PDBe:3h4v, PDBj:3h4v
PDBsum3h4v
PubMed18245389
UniProtQ01782|PTR1_LEIMA Pteridine reductase 1 (Gene Name=PTR1)

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