Structure of PDB 3h0s Chain C

Receptor sequence
>3h0sC (length=668) Species: 4932 (Saccharomyces cerevisiae) [Search protein sequence]
WLQPKRYKAHLMGTTYVYDFPELFRQASSSQWKNFSADVKLTDDFFISNE
LIEDENGELTEVEREPGANAIGMVAFKITVKTPEYPRGRQFVVVANDITF
KIGSFGPQEDEFFNKVTEYARKRGIPRIYLAANSGARIGMAEEIVPLFQV
AWNDAANPDKGFQYLYLTSEGMETLKKFDKENSVLTERTVINGEERFVIK
TIIGSEDGLGVECLRGSGLIAGATSRAYHDIFTITLVTCRSVGIGAYLVR
LGQRAIQVEGQPIILTGAPAINKMLGREVYTSNLQLGGTQIMYNNGVSHL
TAVDDLAGVEKIVEWMSYVPAKRNMPVPILETKDTWDRPVDFTPTNDETY
DVRWMIEGRETESGFEYGLFDKGSFFETLSGWAKGVVVGRARLGGIPLGV
IGVETRTVENLIPADPANPNSAETLIQEPGQVWHPNSAFKTAQAINDFNN
GEQLPMMILANWRGFSGGQRDMFNEVLKYGSFIVDALVDYKQPIIIYIPP
TGELRGGSWVVVDPTINADQMEMYADVNARAGVLEPQGMVGIKFRREKLL
DTMNRLELLPIYGQISLQFADLHDRSSRMVAKGVISKELEWTEARRFFFW
RLRRRLNEEYLIKRLSHQVGEASRLEKIARIRSWYPASVDHEDDRQVATW
IEENYKTLDDKLKGLKLE
3D structure
PDB3h0s Discovery of small molecule isozyme non-specific inhibitors of mammalian acetyl-CoA carboxylase 1 and 2.
ChainC
Resolution2.43 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 6.3.4.14: biotin carboxylase.
6.4.1.2: acetyl-CoA carboxylase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 B38 C V1923 R1954 F1956 L2025 E2026 Q2028 G2029 V432 R463 F465 L534 E535 Q537 G538
Gene Ontology
Molecular Function
GO:0003989 acetyl-CoA carboxylase activity
GO:0016874 ligase activity

View graph for
Molecular Function
External links
PDB RCSB:3h0s, PDBe:3h0s, PDBj:3h0s
PDBsum3h0s
PubMed20219367
UniProtQ00955|ACAC_YEAST Acetyl-CoA carboxylase (Gene Name=ACC1)

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