Structure of PDB 3g4c Chain C

Receptor sequence
>3g4cC (length=215) Species: 2336 (Thermotoga maritima) [Search protein sequence]
MKIDILDKGFVELVDVMGNDLSAVRAARVSFDEERDRHLIEYLMKHGHET
PFEHIVFTFHVKAPIFVARQWFRHRIASYNELCGRYSKLSYEFYIPSPER
LEGYKTTIPPERVTEKISEIVDKAYRTYLELIESGVPREVARIVLPLNLY
TRFFWTVNARSLMNFLNLRADSHAQWEIQQYALAIARIFKEKCPWTFEAF
LKYAYKGDILKEVQV
3D structure
PDB3g4c An unusual mechanism of thymidylate biosynthesis in organisms containing the thyX gene.
ChainC
Resolution2.05 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.1.1.148: thymidylate synthase (FAD).
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 FAD C T55 E58 I81 N163 R165 T50 E53 I76 N158 R160
BS02 UMP C R74 Q75 R78 R174 R69 Q70 R73 R169
BS03 FAD C N85 E86 C88 N80 E81 C83
BS04 FAD C R78 H79 R80 I81 N169 L173 R174 H178 R73 H74 R75 I76 N164 L168 R169 H173
BS05 UMP C E86 C88 G89 R90 R147 E81 C83 G84 R85 R142
Gene Ontology
Molecular Function
GO:0004799 thymidylate synthase activity
GO:0008168 methyltransferase activity
GO:0050660 flavin adenine dinucleotide binding
GO:0050797 thymidylate synthase (FAD) activity
GO:0070402 NADPH binding
Biological Process
GO:0006231 dTMP biosynthetic process
GO:0006235 dTTP biosynthetic process
GO:0009165 nucleotide biosynthetic process
GO:0032259 methylation

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Molecular Function
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Biological Process
External links
PDB RCSB:3g4c, PDBe:3g4c, PDBj:3g4c
PDBsum3g4c
PubMed19370033
UniProtQ9WYT0|THYX_THEMA Flavin-dependent thymidylate synthase (Gene Name=thyX)

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