Structure of PDB 3g4a Chain C

Receptor sequence
>3g4aC (length=214) Species: 243274 (Thermotoga maritima MSB8) [Search protein sequence]
MKIDILDKGFVELVDVMGNDLSAVRAARVSFKDEERDRHLIEYLMKHGHE
TPFEHIVFTFHVKAPIFVARQWFRHRIASYNELAGRYSKLSYEFYIPSPE
RLEGYKTTIPPERVTEKISEIVDKAYRTYLELIESGVPREVARIVLPLNL
YTRFFWTVNARSLMNFLNLRADSHAQWEIQQYALAIARIFKEKCPWTFEA
FLKYAYKGDILKEV
3D structure
PDB3g4a An unusual mechanism of thymidylate biosynthesis in organisms containing the thyX gene.
ChainC
Resolution1.95 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.1.1.148: thymidylate synthase (FAD).
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 FAD C T55 E58 I81 N163 R165 T51 E54 I77 N159 R161
BS02 UMP C Q75 R78 R174 Q71 R74 R170
BS03 FAD C N85 E86 N81 E82
BS04 FAD C R78 H79 R80 I81 N169 L173 R174 H178 R74 H75 R76 I77 N165 L169 R170 H174
BS05 UMP C E86 A88 G89 R90 R147 E82 A84 G85 R86 R143
Gene Ontology
Molecular Function
GO:0004799 thymidylate synthase activity
GO:0008168 methyltransferase activity
GO:0050660 flavin adenine dinucleotide binding
GO:0050797 thymidylate synthase (FAD) activity
GO:0070402 NADPH binding
Biological Process
GO:0006231 dTMP biosynthetic process
GO:0006235 dTTP biosynthetic process
GO:0009165 nucleotide biosynthetic process
GO:0032259 methylation

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Molecular Function
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Biological Process
External links
PDB RCSB:3g4a, PDBe:3g4a, PDBj:3g4a
PDBsum3g4a
PubMed19370033
UniProtQ9WYT0|THYX_THEMA Flavin-dependent thymidylate synthase (Gene Name=thyX)

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