Structure of PDB 3ff6 Chain C

Receptor sequence
>3ff6C (length=742) Species: 9606 (Homo sapiens) [Search protein sequence]
VTKDLLQAKRFQAQTLGTTYIYDFPEMFRQALFKLWGSPDYPKDILTYTE
LVLDSQGQLVEMNRLPGGNEVGMVAFKMRFKTQEYPEGRDVIVIGNDITF
RIGSFGPGEDLLYLRASEMARAEGIPKIYVAANSGARIGMAEEIKHMFHV
AWVDPEDPHKGFKYLYLTPQDYTRISSLNSVHCKHIEEGGESRYMITDII
GKDDGLGVENLRGSGMIAGESSLAYEEIVTISLVTCRAIGIGAYLVRLGQ
RVIQVENSHIILTGASALNKVLGREVYTSNNQLGGVQIMHYNGVSHITVP
DDFEGVYTILEWLSYMPKDNHSPVPIITPTDPIDREIEFLPSRAPYDPRW
MLAGRPHPTLKGTWQSGFFDHGSFKEIMAPWAQTVVTGRARLGGIPVGVI
AVETRTVEVAVPADPANLDSEAKIIQQAGQVWFPDSAYKTAQAIKDFNRE
KLPLMIFANWRGFSGGMKDMYDQVLKFGAYIVDGLRQYKQPILIYIPPYA
ELRGGSWVVIDATINPLCIEMYADKESRGGVLEPEGTVEIKFRKKDLIKS
MRRIDPAYKKLMEQLGEPDLSDKDRKDLEGRLKAREDLLLPIYHQVAVQF
ADFHDTPGRMLEKGVISDILEWKTARTFLYWRLRRLLLEDQVKQEILQAS
GELHVHIQSMLRRWFVETEGAVKAYLWDNNQVVVQWLEQHWQRSTIRENI
TYLKHDSVLKTIRGLVEENPEVAVDCVIYLSQHISPAERAQV
3D structure
PDB3ff6 The human ACC2 CT-domain C-terminus is required for full functionality and has a novel twist.
ChainC
Resolution3.19 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 6.4.1.2: acetyl-CoA carboxylase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 RCP C V2128 F2160 S2161 E2230 E2232 G2233 E2236 V431 F463 S464 E533 E535 G536 E539 BindingDB: IC50=38nM
BS02 RCP C T1960 A1964 L1965 V1968 T263 A267 L268 V271 BindingDB: IC50=38nM
Gene Ontology
Molecular Function
GO:0003989 acetyl-CoA carboxylase activity
GO:0016874 ligase activity

View graph for
Molecular Function
External links
PDB RCSB:3ff6, PDBe:3ff6, PDBj:3ff6
PDBsum3ff6
PubMed19390150
UniProtO00763|ACACB_HUMAN Acetyl-CoA carboxylase 2 (Gene Name=ACACB)

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