Structure of PDB 3f9z Chain C

Receptor sequence
>3f9zC (length=160) Species: 9606 (Homo sapiens) [Search protein sequence]
KSKAELQSEERKRIDELIESGKEEGMKIDLIDGKGRGVIATKQFSRGDFV
VEFHGDLIEITDAKKREALYAQDPSTGCYMYYFQYLSKTYCVDATRETNR
LGRLINHSKCGNCQTKLHDIDGVPHLILIASRDIAAGEELLYDYGDRSKA
SIEAHPWLKH
3D structure
PDB3f9z Structural origins for the product specificity of SET domain protein methyltransferases.
ChainC
Resolution1.6 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.1.1.-
2.1.1.361: [histone H4]-lysine(20) N-methyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide C F245 Y262 C270 M272 Y273 Y274 Y334 Y336 D338 S343 H347 W349 F53 Y70 C78 M80 Y81 Y82 Y142 Y144 D146 S151 H155 W157
BS02 peptide C L222 S267 L30 S75
BS03 SAH C K226 R228 C270 Y271 L296 N298 H299 Y336 W349 K34 R36 C78 Y79 L104 N106 H107 Y144 W157
Gene Ontology
Molecular Function
GO:0042799 histone H4K20 methyltransferase activity

View graph for
Molecular Function
External links
PDB RCSB:3f9z, PDBe:3f9z, PDBj:3f9z
PDBsum3f9z
PubMed19088188
UniProtQ9NQR1|KMT5A_HUMAN N-lysine methyltransferase KMT5A (Gene Name=KMT5A)

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