Structure of PDB 3f4b Chain C

Receptor sequence
>3f4bC (length=282) Species: 5821 (Plasmodium berghei) [Search protein sequence]
NEICFIAGVGDSNGYGWGIAKELSKRNVKVIFGVWPPVYNIFIKNLESGK
FDKDMIIRMQILDVLPLDAGFDNYDDIDEDTKNNKRYNNLKNYSIEEVAN
LIYNKYGKISMLVHSLANGREVQKSLLDTSRDGYLDAISKSSYSLISLCK
HFCKFMNSGGSVVSLTYQASQKVVPGYGGGMSSAKAALESDTRVLAYYLG
RKYNIRINTISAGPLKSRAATAISFIDYAIDYSEKYAPLKKKLLSTDVGS
VASFLLSKESSAVTGQTIYVDNGLNIMFGPDD
3D structure
PDB3f4b The fatty acid biosynthesis enzyme FabI plays a key role in the development of liver-stage malarial parasites.
ChainC
Resolution2.49 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) Y262 K270
Catalytic site (residue number reindexed from 1) Y177 K185
Enzyme Commision number 1.3.1.9: enoyl-[acyl-carrier-protein] reductase (NADH).
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 NAD C V88 G89 G93 Y94 W114 D153 A154 S200 L201 A202 L250 T251 K270 L300 S302 A304 V9 G10 G14 Y15 W35 D68 A69 S115 L116 A117 L165 T166 K185 L215 S217 A219
BS02 TCL C A202 N203 G204 Y252 Y262 A305 A117 N118 G119 Y167 Y177 A220
Gene Ontology
Molecular Function
GO:0004318 enoyl-[acyl-carrier-protein] reductase (NADH) activity
Biological Process
GO:0006633 fatty acid biosynthetic process

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Molecular Function
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Biological Process
External links
PDB RCSB:3f4b, PDBe:3f4b, PDBj:3f4b
PDBsum3f4b
PubMed19064257
UniProtQ6TEI5

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