Structure of PDB 3eyd Chain C

Receptor sequence
>3eydC (length=151) [Search protein sequence]
VEGEVQIVSTATQTFLATCINGVCWTVYHGAGTRTIASPKGPVIQMYTNV
DQDLVGWPAPQGSRSLTPCTCGSSDLYLVTRHADVIPVRRRGDSRGSLLS
PRPISYLKGSSGGPLLCPAGHAVGLFRAAVCTRGVAKAVDFIPVENLETT
M
3D structure
PDB3eyd Potent inhibitors of HCV-NS3 protease derived from boronic acids.
ChainC
Resolution2.3 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) H57 D81 G137 S139
Catalytic site (residue number reindexed from 1) H29 D53 G109 S111
Enzyme Commision number 2.7.7.48: RNA-directed RNA polymerase.
3.4.21.98: hepacivirin.
3.4.22.-
3.6.1.15: nucleoside-triphosphate phosphatase.
3.6.4.13: RNA helicase.
Interaction with ligand
Site
#
Ligand Ligand
chain
Binding residues on receptor
(original residue number in PDB)
Binding residues on receptor
(residue number reindexed from 1)
Binding affinity
BS01 peptide C A111 V113 A83 V85
BS02 peptide C V29 G31 E32 V33 I35 V36 S37 R62 T63 I64 A65 P88 G90 V1 G3 E4 V5 I7 V8 S9 R34 T35 I36 A37 P60 G62
BS03 ZN C C97 C99 C145 C69 C71 C117
Gene Ontology
Molecular Function
GO:0008236 serine-type peptidase activity
Biological Process
GO:0006508 proteolysis
GO:0019087 transformation of host cell by virus

View graph for
Molecular Function

View graph for
Biological Process
External links
PDB RCSB:3eyd, PDBe:3eyd, PDBj:3eyd
PDBsum3eyd
PubMed19022670
UniProtP26664|POLG_HCV1 Genome polyprotein

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