Structure of PDB 3edr Chain C

Receptor sequence
>3edrC (length=145) Species: 9606 (Homo sapiens) [Search protein sequence]
RDRVPTYQYNMNFEKLGKCIIINNKNFDKVTGMGVRNGTDKDAEALFKCF
RSLGFDVIVYNDCSCAKMQDLLKKASEEDHTNAACFACILLSHGEENVIY
GKDGVTPIKDLTAHFRGDRCKTLLEKPKLFFIQACRGTELDDGIQ
3D structure
PDB3edr Structural basis for executioner caspase recognition of P5 position in substrates.
ChainC
Resolution2.45 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) G385 V386 H444 G445 C486
Catalytic site (residue number reindexed from 1) G34 V35 H93 G94 C135
Enzyme Commision number 3.4.22.60: caspase-7.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide C R387 H444 Q484 C486 R36 H93 Q133 C135
Gene Ontology
Molecular Function
GO:0004197 cysteine-type endopeptidase activity
GO:0008234 cysteine-type peptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:3edr, PDBe:3edr, PDBj:3edr
PDBsum3edr
PubMed18780184
UniProtP55210|CASP7_HUMAN Caspase-7 (Gene Name=CASP7)

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