Structure of PDB 3e22 Chain C

Receptor sequence
>3e22C (length=421) Species: 9913 (Bos taurus) [Search protein sequence]
RECISIHVGQAGVQIGNACWELYCLEHGIQPDGQMPDSFNTFFSETGAGK
HVPRAVFVDLEPTVIDEVRTGTYRQLFHPEQLISGKEDAANNYARGHYTI
GKEIIDLVLDRVRKLADQCTGLQGFLVFHSFGGGTGSGFTSLLMERLSVD
YGKKSKLEFSIYPAPQVSTAVVEPYNSILTTHTTLEHSDCAFMVDNEAIY
DICRRNLDIERPTYTNLNRLMSQIVSSITASLRFDGALNVDLTEFQTNLV
PYPRIHFPLATYAPVISAELSVAEITNACFEPANQMVKCDPRHGKYMACC
LLYRGDVVPKDVNAAIATIKTKRTIQFVDWCPTGFKVGINYQPPTVVPGG
DLAKVQRAVCMLSNTTAVAEAWARLDHKFDLMYAKRAFVHWYVGEGMEEG
EFSEAREDMAALEKDYEEVGA
3D structure
PDB3e22 Structural insight into the inhibition of tubulin by vinca domain peptide ligands
ChainC
Resolution3.8 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.6.5.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 TZT C P325 N329 P309 N313
BS02 GTP C G10 Q11 A12 Q15 I16 E71 D98 S140 G143 G144 T145 G146 I171 S178 N206 Y224 N228 G9 Q10 A11 Q14 I15 E61 D88 S130 G133 G134 T135 G136 I161 S168 N196 Y214 N218
BS03 MG C G144 T145 G134 T135
BS04 LOC C A180 V181 A170 V171
Gene Ontology
Molecular Function
GO:0005200 structural constituent of cytoskeleton
GO:0005525 GTP binding
GO:0016787 hydrolase activity
GO:0046872 metal ion binding
Biological Process
GO:0000226 microtubule cytoskeleton organization
GO:0000278 mitotic cell cycle
GO:0007017 microtubule-based process
Cellular Component
GO:0005737 cytoplasm
GO:0005856 cytoskeleton
GO:0005874 microtubule

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:3e22, PDBe:3e22, PDBj:3e22
PDBsum3e22
PubMed18787557
UniProtQ3ZCJ7|TBA1C_BOVIN Tubulin alpha-1C chain (Gene Name=TUBA1C)

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