Structure of PDB 3du7 Chain C

Receptor sequence
>3du7C (length=438) Species: 9913 (Bos taurus) [Search protein sequence]
RECISIHVGQAGVQIGNACWELYCLEHGIQPDGQMPSDKTIGGGDDSFNT
FFSETGAGKHVPRAVFVDLEPTVIDEVRTGTYRQLFHPEQLISGKEDAAN
NYARGHYTIGKEIIDLVLDRVRKLADQCTGLQGFLVFHSFGGGTGSGFTS
LLMERLSVDYGKKSKLEFSIYPAPQVSTAVVEPYNSILTTHTTLEHSDCA
FMVDNEAIYDICRRNLDIERPTYTNLNRLMSQIVSSITASLRFDGALNVD
LTEFQTNLVPYPRIHFPLATYAPVISAEKAYHEQLSVAEITNACFEPANQ
MVKCDPRHGKYMACCLLYRGDVVPKDVNAAIATIKTKRTIQFVDWCPTGF
KVGINYQPPTVVPGGDLAKVQRAVCMLSNTTAVAEAWARLDHKFDLMYAK
RAFVHWYVGEGMEEGEFSEAREDMAALEKDYEEVGADS
3D structure
PDB3du7 Structural insight into the inhibition of tubulin by vinca domain peptide ligands
ChainC
Resolution4.1 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.6.5.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 HOS C P325 N329 V353 P324 N328 V352
BS02 GTP C Q11 A12 I16 E71 D98 S140 G142 G144 T145 G146 I171 P173 S178 N206 Y224 N228 Q10 A11 I15 E70 D97 S139 G141 G143 T144 G145 I170 P172 S177 N205 Y223 N227
BS03 CN2 C S178 A180 S177 A179
Gene Ontology
Molecular Function
GO:0005200 structural constituent of cytoskeleton
GO:0005525 GTP binding
GO:0016787 hydrolase activity
GO:0046872 metal ion binding
Biological Process
GO:0000226 microtubule cytoskeleton organization
GO:0000278 mitotic cell cycle
GO:0007017 microtubule-based process
Cellular Component
GO:0005737 cytoplasm
GO:0005856 cytoskeleton
GO:0005874 microtubule

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:3du7, PDBe:3du7, PDBj:3du7
PDBsum3du7
PubMed18787557
UniProtQ3ZCJ7|TBA1C_BOVIN Tubulin alpha-1C chain (Gene Name=TUBA1C)

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