Structure of PDB 3dqw Chain C

Receptor sequence
>3dqwC (length=276) Species: 9031 (Gallus gallus) [Search protein sequence]
DAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAF
LQEAQVMKKLRHEKLVQLYAVVSEEPIYIVIEYMSKGSLLDFLKGEMGKY
LRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGL
ARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTT
KGRVPYPGMVNREVLDQVERGYRMPCPPECPESLHDLMCQCWRKDPEERP
TFEYLQAFLEDYFTSTEPQYQPGENL
3D structure
PDB3dqw Activation of tyrosine kinases by mutation of the gatekeeper threonine.
ChainC
Resolution2.017 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D386 R388 A390 N391 D404 F424
Catalytic site (residue number reindexed from 1) D129 R131 A133 N134 D147 F167
Enzyme Commision number 2.7.10.2: non-specific protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 AGS C L273 G274 A293 I338 M341 L393 D404 L16 G17 A36 I81 M84 L136 D147
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:3dqw, PDBe:3dqw, PDBj:3dqw
PDBsum3dqw
PubMed18794843
UniProtP00523|SRC_CHICK Proto-oncogene tyrosine-protein kinase Src (Gene Name=SRC)

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