Structure of PDB 3d5q Chain C

Receptor sequence
>3d5qC (length=253) Species: 9606 (Homo sapiens) [Search protein sequence]
LNEEFRPEMLQGKKVIVTGASKGIGREMAYHLAKMGAHVVVTARSKETLQ
KVVSHCLELGAASAHYIAGTMEDMTFAEQFVAQAGKLMGGLDMLILNHIT
NTSLNLFHDDIHHVRKSMEVNFLSYVVLTVAALPMLKQSNGSIVVVSSLA
GKVAYPMVAAYSASKFALDGFFSSIRKEYSVSRVNVSITLCVLGLIDTET
AMKAVQAAPKEECALEIIKGGALRQEEVYYDSSLWTTLLIRNPSRKILEF
LYS
3D structure
PDB3d5q Distinctive molecular inhibition mechanisms for selective inhibitors of human 11beta-hydroxysteroid dehydrogenase type 1.
ChainC
Resolution2.55 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) S170 Y183 K187
Catalytic site (residue number reindexed from 1) S148 Y161 K165
Enzyme Commision number 1.1.1.146: 11beta-hydroxysteroid dehydrogenase.
1.1.1.201: 7beta-hydroxysteroid dehydrogenase (NADP(+)).
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 NAP C G41 S43 K44 G45 I46 A65 R66 S67 T92 M93 N119 I121 S170 Y183 K187 L215 L217 I218 T220 T222 A223 G19 S21 K22 G23 I24 A43 R44 S45 T70 M71 N97 I99 S148 Y161 K165 L193 L195 I196 T198 T200 A201
BS02 T30 C T124 S125 S170 L171 Y177 Y183 T102 S103 S148 L149 Y155 Y161 BindingDB: IC50=1.6nM
Gene Ontology
Molecular Function
GO:0005496 steroid binding
GO:0016491 oxidoreductase activity
GO:0042803 protein homodimerization activity
GO:0047022 7-beta-hydroxysteroid dehydrogenase (NADP+) activity
GO:0050661 NADP binding
GO:0070524 11-beta-hydroxysteroid dehydrogenase (NADP+) activity
GO:0102196 cortisol dehydrogenase activity
Biological Process
GO:0006706 steroid catabolic process
GO:0008202 steroid metabolic process
GO:0030324 lung development
Cellular Component
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0016020 membrane
GO:0043231 intracellular membrane-bounded organelle

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:3d5q, PDBe:3d5q, PDBj:3d5q
PDBsum3d5q
PubMed18789704
UniProtP28845|DHI1_HUMAN 11-beta-hydroxysteroid dehydrogenase 1 (Gene Name=HSD11B1)

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