Structure of PDB 3cs9 Chain C

Receptor sequence
>3cs9C (length=243) Species: 9606 (Homo sapiens) [Search protein sequence]
YDKWEMERTDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLEVEEFLKE
AAVMKEIKHPNLVQLLGVCTREPPFYIITEFMTYGNLLDYLRECNRQEVN
AVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHLVKVADFGPIK
WTAPESLAYNKFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYELLEK
DYRMERPEGCPEKVYELMRACWQWNPSDRPSFAEIHQAFETMF
3D structure
PDB3cs9 Characterization of AMN107, a selective inhibitor of native and mutant Bcr-Abl
ChainC
Resolution2.21 Å
3D
structure
Catalytic site residues are labeled in the structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Catalytic site (original residue number in PDB) D363 A365 R367 N368 D381 P402
Catalytic site (residue number reindexed from 1) D127 A129 R131 N132 D145 P148
Enzyme Commision number 2.7.10.2: non-specific protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 NIL C L248 Y253 A269 K271 E286 V289 M290 I313 T315 F317 M318 H361 A380 D381 F382 L17 Y22 A38 K40 E50 V53 M54 I77 T79 F81 M82 H125 A144 D145 F146 MOAD: ic50<33uM
BindingDB: Kd=10nM,IC50=20nM,Ki=1nM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:3cs9, PDBe:3cs9, PDBj:3cs9
PDBsum3cs9
PubMed15710326
UniProtP00519|ABL1_HUMAN Tyrosine-protein kinase ABL1 (Gene Name=ABL1)

[Back to BioLiP]