Structure of PDB 3clx Chain C

Receptor sequence
>3clxC (length=98) Species: 9606 (Homo sapiens) [Search protein sequence]
LPRNPSMADYEARIFTFGTWIYSVNKEQLARAGFYALGEGDKVKCFHCGG
GLTDWKPSEDPWEQHAKWYPGCKYLLEQKGQEYINNIHLTHSLEECLV
3D structure
PDB3clx Targeting the X-linked inhibitor of apoptosis protein through 4-substituted azabicyclo[5.3.0]alkane smac mimetics. Structure, activity, and recognition principles.
ChainC
Resolution2.7 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.3.2.27: RING-type E3 ubiquitin transferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN C C300 C303 H320 C327 C45 C48 H65 C72
BS02 X22 C E337 N340 H343 L344 S347 E82 N85 H88 L89 S92 BindingDB: IC50=290nM
BS03 X22 C K297 G306 L307 T308 W310 E314 W323 Y324 K42 G51 L52 T53 W55 E59 W68 Y69 BindingDB: IC50=290nM
BS04 X22 C C303 K322 W323 Y324 P325 C48 K67 W68 Y69 P70 BindingDB: IC50=290nM
External links
PDB RCSB:3clx, PDBe:3clx, PDBj:3clx
PDBsum3clx
PubMed18851976
UniProtP98170|XIAP_HUMAN E3 ubiquitin-protein ligase XIAP (Gene Name=XIAP)

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