Structure of PDB 3c6m Chain C

Receptor sequence
>3c6mC (length=291) Species: 9606 (Homo sapiens) [Search protein sequence]
RHSTLDFMLVLLDLQSQGKEEIDSILNKVEERMKRVKRLPPIVRGGAIDR
YWPTADGRLVEYDIDEVVYDEDSPYQNIKILHSKQFGNILILSGDVNLAE
SDLAYTRAIMGSGKEDYTGKDVLILGGGDGGILCEIVKLKPKMVTMVEID
QMVIDGCKKYMRKTCGDVLDNLKGDCYQVLIEDCIPVLKRYAKEGREFDY
VINDLTAVPISTSPSTWEFLRLILDLSMKVLKQDGKYFTQGNCVNLTEAL
SLYEEQLGRLYCPVEFSKEIVCVPSYLELWVFYTVWKKAKP
3D structure
PDB3c6m Crystal structure of human spermine synthase: implications of substrate binding and catalytic mechanism.
ChainC
Resolution2.45 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number 2.5.1.22: spermine synthase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 SPM C D167 V168 N169 Y177 D201 D276 Q315 Y351 E353 W355 D95 V96 N97 Y105 D129 D204 Q240 Y276 E278 W280
BS02 MTA C L164 N169 G198 G199 D201 V219 E220 I221 D255 C256 D276 L277 T278 I282 L92 N97 G126 G127 D129 V147 E148 I149 D183 C184 D204 L205 T206 I210 MOAD: Ki=0.3uM
Gene Ontology
Molecular Function
GO:0016740 transferase activity
GO:0016768 spermine synthase activity
Biological Process
GO:0006555 methionine metabolic process
GO:0006595 polyamine metabolic process
GO:0006596 polyamine biosynthetic process
GO:0006597 spermine biosynthetic process
GO:0008215 spermine metabolic process
Cellular Component
GO:0005829 cytosol
GO:0070062 extracellular exosome

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:3c6m, PDBe:3c6m, PDBj:3c6m
PDBsum3c6m
PubMed18367445
UniProtP52788|SPSY_HUMAN Spermine synthase (Gene Name=SMS)

[Back to BioLiP]