Structure of PDB 3c4e Chain C

Receptor sequence
>3c4eC (length=272) Species: 9606 (Homo sapiens) [Search protein sequence]
LESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNG
TRVPMEVVLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFI
TERGALQEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELK
LIDFGSGALLKDTVYTDFDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLY
DMVCGDIPFEHDEEIIRGQVFFRQRVSSECQHLIRWCLALRPSDRPTFEE
IQNHPWMQDVLLPQETAEIHLH
3D structure
PDB3c4e Discovery of a selective inhibitor of oncogenic B-Raf kinase with potent antimelanoma activity
ChainC
Resolution1.98 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D167 K169 N172 D186 L193 T204
Catalytic site (residue number reindexed from 1) D134 K136 N139 D153 L160 T171
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 C4E C F49 A65 K67 R122 L174 I185 D186 F16 A32 K34 R89 L141 I152 D153 MOAD: ic50~100uM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation
GO:0043066 negative regulation of apoptotic process

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Molecular Function
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Biological Process
External links
PDB RCSB:3c4e, PDBe:3c4e, PDBj:3c4e
PDBsum3c4e
PubMed18287029
UniProtP11309|PIM1_HUMAN Serine/threonine-protein kinase pim-1 (Gene Name=PIM1)

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