Structure of PDB 3bze Chain C

Receptor sequence

>3bzeC (length=273) Species: 9606 (Homo sapiens) [Search protein sequence]

SHSLKYFHTSVSRPGRGEPRFISVGYVDDTQFVRFDNDAASPRMVPRAPW
MEQEGSEYWDRETRSARDTAQIFRVNLRTLRGYYNQSEAGSHTLQWMHGC
ELGPDRRFLRGYEQFAYDGKDYLTLNEDLRSWTAVDTAAQISEQKSNDAS
EAEHQRAYLEDTCVEWLHKYLEKGKETLLHLEPPKTHVTHHPISDHEATL
RCWALGFYPAEITLTWQQDGEGHTQDTELVETRPAGDGTFQKWAAVVVPS
GEEQRYTCHVQHEGLPEPVTLRW

3D structure

PDB

3bze Subtle changes in peptide conformation profoundly affect recognition of the non-classical MHC class I molecule HLA-E by the CD94-NKG2 natural killer cell receptors

Chain

Resolution

2.5 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	peptide	C	Y7 E63 S66 A67 I73 N77 T80 Y84 W97 W133 S143 K146 S147 E152 Q156 Y159 W167	Y6 E62 S65 A66 I72 N76 T79 Y83 W96 W132 S142 K145 S146 E151 Q155 Y158 W166
BS02	peptide	C	R65 D69 Q72	R64 D68 Q71

External links

PDB	RCSB:3bze, PDBe:3bze, PDBj:3bze
PDBsum	3bze
PubMed	18339401
UniProt	P13747\|HLAE_HUMAN HLA class I histocompatibility antigen, alpha chain E (Gene Name=HLA-E)

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