Structure of PDB 3brg Chain C

Receptor sequence

>3brgC (length=414) Species: 10090 (Mus musculus)

PPKRLTREAMRNYLKERGDQTVLILHAKVAQKSYGNEKRFFCPPPCVYLM
GSGWKKKKEQMERDGCSEQESQPCAFIGIGNSDQEMQQLNLEGKNYCTAK
TLYISDSDKRKHFMLSVKMFYGNSDDIGVFLSKRIKVISKPSKKKLKNAD
LCIASGTKVALFNRLRSQTVSTRYLHVEGGNFHASSQQWGAFYIHLLDDD
ETVRDGYIHYGQTVKLVCSVTGMALPRLIIRKVDKQTALLDADDPVSQLH
KCAFYLKDTERMYLCLSQERIIQFQATPCPKEQNKEMINDGASWTIISTD
KAEYTFYEGMGPVLAPVTPVPVVESLQLNGGGDVAMLELTGQNFTPNLRV
WFGDVEAETMYRCGESMLCVVPDISAFREGWRWVRQPVQVPVTLVRNDGV
IYSTSLTFTYTPEP

3D structure

• PDB: 3brg RAM-induced Allostery Facilitates Assembly of a Notch Pathway Active Transcription Complex.
• Chain: C
• Resolution: 2.2 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	dna	C	K84 Y86 S191 K192 R220 S221 Q222	K32 Y34 S139 K140 R166 S167 Q168	PDBbind-CN: Kd=60nM
BS02	dna	C	K90 R91 F92 K192 R218 R220 K295 K311	K38 R39 F40 K140 R164 R166 K235 K251	PDBbind-CN: Kd=60nM

Gene Ontology

Molecular Function

• GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
• GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific
• GO:0003677 DNA binding
• GO:0003700 DNA-binding transcription factor activity

Biological Process

• GO:0006355 regulation of DNA-templated transcription
• GO:0006357 regulation of transcription by RNA polymerase II

Cellular Component

• GO:0005634 nucleus

External links

• PDB: RCSB:3brg, PDBe:3brg, PDBj:3brg
• PDBsum: 3brg
• PubMed: 18381292
• UniProt: P31266|SUH_MOUSE Recombining binding protein suppressor of hairless (Gene Name=Rbpj)