Structure of PDB 3bgv Chain C

Receptor sequence
>3bgvC (length=270) Species: 9606 (Homo sapiens) [Search protein sequence]
IFYLRNFNNWMKSVLIGEFLEKVRQKRDITVLDLGCGKGGDLLKWKKGRI
NKLVCTDIADVSVKQCQQRYEDMKNRRDYIFSAEFITADSSKELLIDKFR
DPQMCFDICSCQFVCHYSFESYEQADMMLRNACERLSPGGYFIGTTPNSF
ELIRRLEASETESFGNEIYTVKFQKKGDYPLFGCKYDFNLEGVDVPEFLV
YFPLLNEMAKKYNMKLVYKKTFLEFYEEKIKNNENKMLLKRMQRLPLGTL
SKSEWEATSIYLVFAFEKQQ
3D structure
PDB3bgv The crystal structure of human RNA (guanine-7-) methyltransferase in complex with SAH.
ChainC
Resolution2.3 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.1.1.56: mRNA (guanine-N(7))-methyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 SAH C K16 G41 D63 I64 S98 Q120 V122 Y125 M136 K12 G35 D57 I58 S90 Q112 V114 Y117 M128
Gene Ontology
Molecular Function
GO:0004482 mRNA 5'-cap (guanine-N7-)-methyltransferase activity
Biological Process
GO:0006370 7-methylguanosine mRNA capping

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Molecular Function
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Biological Process
External links
PDB RCSB:3bgv, PDBe:3bgv, PDBj:3bgv
PDBsum3bgv
PubMed
UniProtO43148|MCES_HUMAN mRNA cap guanine-N7 methyltransferase (Gene Name=RNMT)

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