Structure of PDB 3az9 Chain C

Receptor sequence
>3az9C (length=144) Species: 5833 (Plasmodium falciparum) [Search protein sequence]
TSIDIEDIKKILPHRYPFLLVDKVIYMQPNKTIIGLKQVSTNEPFFNGHF
PQKQIMPGVLQIEALAQLAGILCLKSDDSQKNNLFLFAGVDGVRWKKPVL
PGDTLTMQANLISFKSSLGIAKLSGVGYVNGKVVINISEMTFAL
3D structure
PDB3az9 Structural basis for the functional and inhibitory mechanisms of beta-hydroxyacyl-acyl carrier protein dehydratase (FabZ) of Plasmodium falciparum
ChainC
Resolution2.75 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) H133 I139 G142 V143 E147
Catalytic site (residue number reindexed from 1) H49 I55 G58 V59 E63
Enzyme Commision number 4.2.1.59: 3-hydroxyacyl-[acyl-carrier-protein] dehydratase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 K91 C H98 E147 A150 F169 L170 F171 F226 H14 E63 A66 F85 L86 F87 F142 PDBbind-CN: -logKd/Ki=6.00,Kd~1uM
BS02 K91 C H133 F134 P141 G142 H49 F50 P57 G58 PDBbind-CN: -logKd/Ki=6.00,Kd~1uM
Gene Ontology
Molecular Function
GO:0016836 hydro-lyase activity
Biological Process
GO:0006633 fatty acid biosynthetic process

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Molecular Function
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Biological Process
External links
PDB RCSB:3az9, PDBe:3az9, PDBj:3az9
PDBsum3az9
PubMed21843645
UniProtQ965D7

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