Structure of PDB 3ael Chain C

Receptor sequence
>3aelC (length=387) Species: 5759 (Entamoeba histolytica) [Search protein sequence]
AQDITTTLLHPKGDHVLHSHAYPIFQTSTFCFDSTQQGADLFMGKGEGHI
YSRLGNPTVEQFEEMVCSIEGAAGSAAFGSGMGAISSSTLAFLQKGDHLI
AGDTLYGCTVSLFTHWLPRFGIEVDLIDTSDVEKVKAAWKPNTKMVYLES
PANPTCKVSDIKGIAVVCHERGARLVVDATFTSPCFLKPLELGADIALHS
VSKYINGHGDVIGGVSSAKTAEDIATIKFYRKDAGSLMAPMDAFLCARGM
KTLPIRMQIHMENGLKVAKFLEQHEKIVKVNHPGLESFPGHDIAKKQMTG
YGSTFLFEMKSFEAAKKLMEHLKVCTLAVSLGCVDTLIEHPASMTHAAVP
ENIMRKQGITPELVRISVGIENVDDIIADLKQALELW
3D structure
PDB3ael Crystal structure of Entamoeba histolytica methionine gamma-lyase 1
ChainC
Resolution2.0 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 4.4.1.11: methionine gamma-lyase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 2LM C Y1053 R1055 Y51 R53
BS02 2LM C G1083 M1084 Y1108 E1151 N1155 D1180 T1182 S1202 S1204 K1205 V1331 S1332 T1347 R1367 G81 M82 Y106 E149 N153 D178 T180 S200 S202 K203 V329 S330 T345 R365
Gene Ontology
Molecular Function
GO:0016829 lyase activity
GO:0016846 carbon-sulfur lyase activity
GO:0018826 methionine gamma-lyase activity
GO:0030170 pyridoxal phosphate binding
Biological Process
GO:0019346 transsulfuration
Cellular Component
GO:0005737 cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:3ael, PDBe:3ael, PDBj:3ael
PDBsum3ael
PubMed
UniProtQ86D28

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