Structure of PDB 3aaw Chain C

Receptor sequence
>3aawC (length=392) Species: 1718 (Corynebacterium glutamicum) [Search protein sequence]
MALVVQKYGGSSLESAERIRNVAERIVATKKAGNDVVVVCSAMGDTTDEL
LELAAAVNPVPPAREMDMLLTAGERISNALVAMAIESLGAEAQSFTGSQD
VTPGRVREALDEGKICIVAGFQGVNKRDVTTLGRGGSDTTAVALAAALNA
DVCEIYSDVDGVYTADPRIVPNAQKLEKLSFEEMLELAAVGSKILVLRSV
EYARAFNVPLRVRSSYSNDPGTLIAGSMEDIPVEEAVLTGVATDKSEAKV
TVLGISDKPGEAAKVFRALADAEINIDMVLQNVSSVEDGTTDITFTCPRS
DGRRAMEILKKLQVQGNWTNVLYDDQVGKVSLVGAGMKSHPGVTAEFMEA
LRDVNVNIELISTSEIRISVLIREDDLDAAARALHEQFQLGG
3D structure
PDB3aaw Mechanism of concerted inhibition of {alpha}2{beta}2-type heterooligomeric aspartate kinase from Corynebacterium glutamicum
ChainC
Resolution2.5 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.2.4: aspartate kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 LYS C M354 H357 T361 S381 M337 H340 T344 S364
BS02 THR C K275 G277 E278 A279 Q298 K258 G260 E261 A262 Q281
BS03 LYS C K7 S41 G153 S154 D155 K7 S41 G136 S137 D138
BS04 THR C N374 I375 N357 I358
Gene Ontology
Molecular Function
GO:0004072 aspartate kinase activity
GO:0005524 ATP binding
GO:0016301 kinase activity
Biological Process
GO:0008652 amino acid biosynthetic process
GO:0009085 lysine biosynthetic process
GO:0009088 threonine biosynthetic process
GO:0009089 lysine biosynthetic process via diaminopimelate
GO:0009090 homoserine biosynthetic process
GO:0016310 phosphorylation
GO:0019877 diaminopimelate biosynthetic process
Cellular Component
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:3aaw, PDBe:3aaw, PDBj:3aaw
PDBsum3aaw
PubMed20573952
UniProtP26512|AK_CORGL Aspartokinase (Gene Name=lysC)

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