Structure of PDB 2z86 Chain C

Receptor sequence
>2z86C (length=603) Species: 562 (Escherichia coli) [Search protein sequence]
AVIDIDAATKIMCSNAKAISLNEVEKNEIISKYREITAKKSERAELKEVE
PIPLDWPSDLTLPPLPESTNDYVWAGKRKELDDQLIIDGLSIVIPTYNRA
KILAITLACLCNQKTIYDYEVIVADDGSKENIEEIVREFESLLNIKYVRQ
KDYGYQLCAVRNLGLRAAKYNYVAILDCDMAPNPLWVQSYMELLAVDDNV
ALIGPRKYIDTSKHTYLDFLSQKSLINEIPEIITNQNKSVDWRIEHFKNT
DNLRLCNTPFRFFSGGNVAFAKKWLFRAGWFDEEFTHWGGEDNEFGYRLY
REGCYFRSVEGAMAYHQEPPGKENITVQLLQQKVPYFYRKKEKIESATLK
RVPLVSIYIPAYNCSKYIVRCVESALNQTITDLEVCICDDGSTDDTLRIL
QEHYANHPRVRFISQKNKGIGSASNTAVRLCRGFYIGQLDSDDFLEPDAV
ELCLDEFRKDLSLACVYTTNRNIDREGNLISNGYNWPIYSREKLTSAMIC
HHFRMFTARAWNLTEGFNESISNAVDYDMYLKLSEVGPFKHINKICYNRV
LHGENTSIKKLDIQKENHFKVVNESLSRLGIKKYKYSPLTNLNECRKYTW
EKI
3D structure
PDB2z86 Crystal structure of chondroitin polymerase from Escherichia coli K4.
ChainC
Resolution2.4 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.4.1.175: glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N- acetylgalactosaminyltransferase.
2.4.1.226: N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 UDP C P157 T158 Y159 R161 D188 Y217 L219 D239 C240 P95 T96 Y97 R99 D126 Y155 L157 D177 C178
BS02 UGA C P439 Y441 D469 G498 I499 D519 S520 H581 N602 A603 V604 D605 H631 P360 Y362 D390 G419 I420 D440 S441 H502 N523 A524 V525 D526 H552
BS03 MN C D241 H386 D179 H316
BS04 MN C D521 H631 D442 H552
Gene Ontology
Molecular Function
GO:0016757 glycosyltransferase activity
GO:0046872 metal ion binding
GO:0047238 glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity
GO:0050510 N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity

View graph for
Molecular Function
External links
PDB RCSB:2z86, PDBe:2z86, PDBj:2z86
PDBsum2z86
PubMed18771653
UniProtQ8L0V4|CHS_ECOLX Chondroitin synthase (Gene Name=kfoC)

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