Structure of PDB 2yic Chain C

Receptor sequence
>2yicC (length=806) Species: 1772 (Mycolicibacterium smegmatis) [Search protein sequence]
NARVIELIAAYRNRGHLMADIDPLRLDNTRFTLWDLDREFKKLRDILSVL
RDAYCRHVGVEYTHILEPEQQRWIQERVETKHDKPTVAEQKYILSKLNAA
EAFETFLQTKYVGQKRFSLEGAETVIPMMDAVIDQCAEHGLDEVVIAMPH
RGRLNVLANIVGKPYSQIFSEGDVKYHLGATGTYIQMFGDNDIEVSLTAN
PSHLEAVDPVLEGLVRAKQDLLDTGEEGRFSVVPLMLHGDAAFAGQGVVA
ETLNLALLRGYRTGGTIHIVVNNQIGFTTAPTDSRSSEYCTDVAKMIGAP
IFHVNGDDPEACAWVARLAVDFRQAFKKDVVIDMLCYRRRGHNEGDDPSM
TQPYMYDVIDTKRGSRKAYTEALIGRGDISMKEAEDALRDYQGQLERVFN
EVRELEKHELATAVDKAMLQRIGDAHLALPEGFTVHPRVRPVLEKRREMA
YEGRIDWAFAELLALGSLIAEGKLVRLSGQDTQRGTFTQRHAVIVDRKTG
EEFTPLQLLATNPDGTPTGGKFLVYNSALSEFAAVGFEYGYSVGNPDAMV
LWEAQFGDFVNGAQSIIDEFISSGEAKWGQLSDVVLLLPHGHEGQGPDHT
SGRIERFLQLWAEGSMTIAMPSTPANYFHLLRRHGKDGIQRPLIVFTPKS
MLRNKAAVSDIRDFTESKFRSVLEEPMYTDGEGDRNKVTRLLLTSGKIYY
ELAARKAKENREDVAIVRIEQLAPLPRRRLAETLDRYPNVKEKFWVQEEP
ANQGAWPSFGLTLPEILPDHFTGLKRISRRAMSAPSSGSSKVHAVEQQEI
LDTAFG
3D structure
PDB2yic Functional Plasticity and Allosteric Regulation of Alpha-Ketoglutarate Decarboxylase in Central Mycobacterial Metabolism.
ChainC
Resolution1.96 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 1.2.4.2: oxoglutarate dehydrogenase (succinyl-transferring).
2.2.1.5: 2-hydroxy-3-oxoadipate synthase.
2.3.1.61: dihydrolipoyllysine-residue succinyltransferase.
4.1.1.71: 2-oxoglutarate decarboxylase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 TPP C R540 S604 L606 G644 D645 A646 A647 N678 I680 G681 H747 R151 S202 L204 G239 D240 A241 A242 N273 I275 G276 H342
BS02 MG C D645 N678 I680 D240 N273 I275
BS03 CA C D1004 H1055 D1058 I1060 D583 H634 D637 I639
BS04 TPP C Q901 L950 E952 Q976 F980 Q480 L529 E531 Q555 F559
Gene Ontology
Molecular Function
GO:0016624 oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
GO:0030976 thiamine pyrophosphate binding

View graph for
Molecular Function
External links
PDB RCSB:2yic, PDBe:2yic, PDBj:2yic
PDBsum2yic
PubMed21867916
UniProtA0R2B1|KGD_MYCS2 Multifunctional 2-oxoglutarate metabolism enzyme (Gene Name=kgd)

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