Structure of PDB 2y8c Chain C

Receptor sequence
>2y8cC (length=136) Species: 36329 (Plasmodium falciparum 3D7) [Search protein sequence]
MHLKIVCLSDEVREMYKNHSGLDLFIVKDEVLKPKSTTFVKLGIKAIALQ
VNTSFLLFPRSSISKTPLRLANSIGLIDAGYRGEIIAALDNTSDQEYHIK
KNDKLVQLVSFTGEPLSFELVEELDETSRGEGGFGS
3D structure
PDB2y8c Beta-Branched Acyclic Nucleoside Analogues as Inhibitors of Plasmodium Falciparum Dutpase
ChainC
Resolution2.1 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) S27 R91 S93 L99 D109
Catalytic site (residue number reindexed from 1) S20 R60 S62 L68 D78
Enzyme Commision number 3.6.1.23: dUTP diphosphatase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 DUQ C S92 S93 K96 S61 S62 K65 MOAD: Ki=0.4uM
BS02 DUQ C F46 N103 G106 L107 Y112 I117 F39 N72 G75 L76 Y81 I86 MOAD: Ki=0.4uM
Gene Ontology
Molecular Function
GO:0000287 magnesium ion binding
GO:0004170 dUTP diphosphatase activity
GO:0016787 hydrolase activity
GO:0042802 identical protein binding
GO:0046872 metal ion binding
Biological Process
GO:0006226 dUMP biosynthetic process
GO:0006260 DNA replication
GO:0006399 tRNA metabolic process
GO:0009117 nucleotide metabolic process
GO:0046081 dUTP catabolic process

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Molecular Function
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Biological Process
External links
PDB RCSB:2y8c, PDBe:2y8c, PDBj:2y8c
PDBsum2y8c
PubMed21411327
UniProtQ8II92

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