Structure of PDB 2y7j Chain C

Receptor sequence
>2y7jC (length=284) Species: 9606 (Homo sapiens) [Search protein sequence]
ELPDWAAAKEFYQKYDPKDVIGRGVSSVVRRCVHRATGHEFAVKIMEVTA
ERLSPEQLEEVREATRRETHILRQVAGHPHIITLIDSYESSSFMFLVFDL
MRKGELFDYLTEKVALSEKETRSIMRSLLEAVSFLHANNIVHRDLKPENI
LLDDNMQIRLSDFGFSCHLEPGEKLRELCGTPGYLAPEILKCSMDETHPG
YGKEVDLWACGVILFTLLAGSPPFWHRRQILMLRMIMEGQYQFSSPEWDD
RSSTVKDLISRLLQVDPEARLTAEQALQHPFFER
3D structure
PDB2y7j Structure of Human Phosphorylase Kinase, Gamma 2
ChainC
Resolution2.5 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D153 K155 E157 N158 D171 T190
Catalytic site (residue number reindexed from 1) D144 K146 E148 N149 D162 T181
Enzyme Commision number 2.7.11.19: phosphorylase kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 B49 C I30 A51 F107 M110 R111 G113 D117 L160 I21 A42 F98 M101 R102 G104 D108 L151 BindingDB: Kd=5.9nM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004689 phosphorylase kinase activity
GO:0005516 calmodulin binding
GO:0005524 ATP binding
GO:0019865 immunoglobulin binding
Biological Process
GO:0005977 glycogen metabolic process
GO:0006468 protein phosphorylation
Cellular Component
GO:0005964 phosphorylase kinase complex

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Biological Process
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Cellular Component
External links
PDB RCSB:2y7j, PDBe:2y7j, PDBj:2y7j
PDBsum2y7j
PubMed
UniProtP15735|PHKG2_HUMAN Phosphorylase b kinase gamma catalytic chain, liver/testis isoform (Gene Name=PHKG2)

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