Structure of PDB 2xyo Chain C

Receptor sequence
>2xyoC (length=366) Species: 818 (Bacteroides thetaiotaomicron) [Search protein sequence]
SDKNVAIIGGGPVGLTMAKLLQQNGIDVSVYERDNDREARIFGGTLDLHK
GSGQEAMKKAGLLQTYYDLALPMGVNIADEKGNILSTKNVKPENRFDNPE
INRNDLRAILLNSLENDTVIWDRKLVMLEPGKKKWTLTFENKPSETADLV
ILANGGMSKVRKFVTDTEVEETGTFNIQADIHQPEINCPGFFQLCNGNRL
MASHQGNLLFANPNNNGALHFGISFKTPDEWTQVDFQNRNSVVDFLLKEF
SDWDERYKELIHTTLSFVGLATRIFPLEKPWKSKRPLPITMIGDAAHLMP
PFAGQGVNSGLVDALILSDNLADGKFNSIEEAVKNYEQQMFIYGKEAQEE
STQNEIEMFKPDFTFQ
3D structure
PDB2xyo Structural Basis for a New Tetracycline Resistance Mechanism Relying on the Tetx Monooxygenase.
ChainC
Resolution3.0 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 1.14.13.231: tetracycline 11a-monooxygenase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 FAD C G23 G25 P26 V27 Y45 E46 R47 R117 K138 L139 N168 Q192 G310 D311 P318 G321 G323 V324 G9 G11 P12 V13 Y31 E32 R33 R103 K124 L125 N154 Q178 G293 D294 P301 G304 G306 V307
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0004497 monooxygenase activity
GO:0071949 FAD binding
Biological Process
GO:0046677 response to antibiotic
Cellular Component
GO:0005737 cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:2xyo, PDBe:2xyo, PDBj:2xyo
PDBsum2xyo
PubMed21402075
UniProtQ93L51|TETX_BACT4 Flavin-dependent monooxygenase (Gene Name=tetX2)

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