Structure of PDB 2xyn Chain C

Receptor sequence
>2xynC (length=262) Species: 9606 (Homo sapiens) [Search protein sequence]
WEMERTDITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLKTMEVEEFLKE
AAVMKEIKHPNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRECNREEVT
AVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHVVKVADFGLSR
LMTGDTYTAHAGAKFPIKWTAPESLAYNTFSIKSDVWAFGVLLWEIATYG
MSPYPGIDLSQVYDLLEKGYRMEQPEGCPPKVYELMRACWKWSPADRPSF
AETHQAFETMFH
3D structure
PDB2xyn Crystal Structures of Abl-Related Gene (Abl2) in Complex with Imatinib, Tozasertib (Vx-680), and a Type I Inhibitor of the Triazole Carbothioamide Class.
ChainC
Resolution2.81 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D409 A411 R413 N414 D427 P448
Catalytic site (residue number reindexed from 1) D127 A129 R131 N132 D145 P166
Enzyme Commision number 2.7.10.2: non-specific protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 VX6 C L294 Y299 V302 A315 K317 T361 Y363 M364 P365 Y366 G367 L416 D427 L14 Y19 V22 A35 K37 T79 Y81 M82 P83 Y84 G85 L134 D145 BindingDB: Kd=4nM
BS02 VX6 C L353 P355 L71 P73 BindingDB: Kd=4nM
BS03 VX6 C K446 I449 S492 Y495 K164 I167 S210 Y213 BindingDB: Kd=4nM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:2xyn, PDBe:2xyn, PDBj:2xyn
PDBsum2xyn
PubMed21417343
UniProtP42684|ABL2_HUMAN Tyrosine-protein kinase ABL2 (Gene Name=ABL2)

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