Structure of PDB 2xlr Chain C

Receptor sequence

>2xlrC (length=452) Species: 230105 (Methylophaga aminisulfidivorans) [Search protein sequence]

SMATRIAILGAGPSGMAQLRAFQSAQEKGAEIPELVCFEKQADWGGQWNY
TWRTGLDENGEPVHSSMYRYLWSDGPKECLEFADYTFDEHFGKPIASYPP
REVLWDYIKGRVEKAGVRKYIRFNTAVRHVEFNEDSQTFTVTVQDHTTDT
IYSAAFDYVVCCTGHFSTPYVPEFEGFEKFGGRILHAHDFRDALEFKDKT
VLLVGSSYSAEDIGSQCYKYGAKKLISCYRTAPMGYKWPENWDERPNLVR
VDTENAYFADGSSEKVDAIILCTGYIHHFPFLNDDLRLVTNNRLWPLNLY
KGVVWEDNPKFFYIGMQDQWYSFNMFDAQAWYARDVIMGRLPLPSKEEMK
ADSMAWREKELTLVTAEEMYTYQGDYIQNLIDMTDYPSFDIPATNKTFLE
WKHHKKENIMTFRDHSYRSLMTGTMAPKHHTPWIDALDDSLEAYLSDKSE
IP

3D structure

PDB

2xlr Joint functions of protein residues and NADP(H) in oxygen activation by flavin-containing monooxygenase.

Chain

Resolution

2.55 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

1.14.13.148: trimethylamine monooxygenase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	FAD	C	G16 P17 S18 E43 K44 Q45 G50 Q51 W52 H68 M71 D78 V131 T167 F170 Q323 S326	G12 P13 S14 E39 K40 Q41 G46 Q47 W48 H64 M67 D74 V127 T163 F166 Q319 S322
BS02	NAP	C	D78 G209 S210 S211 Y212 S213 R234 T235 N251 C276 T277 D322 Q323	D74 G205 S206 S207 Y208 S209 R230 T231 N247 C272 T273 D318 Q319

Gene Ontology

	Molecular Function
GO:0000166	nucleotide binding
GO:0004497	monooxygenase activity
GO:0004499	N,N-dimethylaniline monooxygenase activity
GO:0042802	identical protein binding
GO:0050660	flavin adenine dinucleotide binding
GO:0050661	NADP binding

View graph for
Molecular Function

External links

PDB	RCSB:2xlr, PDBe:2xlr, PDBj:2xlr
PDBsum	2xlr
PubMed	20807767
UniProt	Q83XK4

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