Structure of PDB 2wwf Chain C

Receptor sequence
>2wwfC (length=212) Species: 36329 (Plasmodium falciparum 3D7) [Search protein sequence]
SHMTDDKKKGKFIVFEGLDRSGKSTQSKLLVEYLKNNNVEVKHLYFPNRE
TGIGQIISKYLKMENSMSNETIHLLFSANRWEHMNEIKSLLLKGIWVVCD
RYAYSGVAYSSGALNLNKTWCMNPDQGLIKPDVVFYLNVPPNYAQNRSDY
GEEIYEKVETQKKIYETYKHFAHEDYWINIDATRKIEDIHNDIVKEVTKI
KVEPEEFNFLWS
3D structure
PDB2wwf Structural Basis for the Efficient Phosphorylation of Aztmp and Dgmp by Plasmodium Falciparum Type I Thymidylate Kinase.
ChainC
Resolution1.89 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.4.8: guanylate kinase.
2.7.4.9: dTMP kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 TMP C D17 F44 L59 F74 R78 R99 S103 G104 Y107 Y153 D19 F46 L61 F76 R80 R101 S105 G106 Y109 Y155
BS02 ADP C R18 G20 K21 S22 T23 R145 I184 R20 G22 K23 S24 T25 R147 I186
Gene Ontology
Molecular Function
GO:0004385 guanylate kinase activity
GO:0004550 nucleoside diphosphate kinase activity
GO:0004798 thymidylate kinase activity
GO:0005524 ATP binding
GO:0016301 kinase activity
GO:0050316 T2-induced deoxynucleotide kinase activity
Biological Process
GO:0006177 GMP biosynthetic process
GO:0006227 dUDP biosynthetic process
GO:0006233 dTDP biosynthetic process
GO:0006235 dTTP biosynthetic process
GO:0009165 nucleotide biosynthetic process
GO:0016310 phosphorylation
GO:0046710 GDP metabolic process
GO:0046940 nucleoside monophosphate phosphorylation
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005739 mitochondrion

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:2wwf, PDBe:2wwf, PDBj:2wwf
PDBsum2wwf
PubMed20353400
UniProtQ8I4S1|KTHY_PLAF7 Thymidylate kinase (Gene Name=TMK)

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