Structure of PDB 2wub Chain C

Receptor sequence
>2wubC (length=228) Species: 9606 (Homo sapiens) [Search protein sequence]
IIGGSSSLPGSHPWLAAIYIGDSFCAGSLVHTCWVVSAAHCFSHSPPRDS
VSVVLGQHFFNRTTDVTQTFGIEKYIPYTLYSVFNPSDHDLVLIRLKKKG
DRCATRSQFVQPICLPEPGSTFPAGHKCQIAGWGHSSSLREALVPLVADH
KCSSPEVYGADISPNMLCAGYFDCKSDACQGDSGGPLACEKNGVAYLYGI
ISWGCRLHKPGVYTRVANYVDWINDRIR
3D structure
PDB2wub Unraveling the Allosteric Mechanism of Serine Protease Inhibition by an Antibody
ChainC
Resolution2.9 Å
3D
structure
Catalytic site residues are labeled in the structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Catalytic site (original residue number in PDB) H57 D102 Q192 G193 D194 S195 G196
Catalytic site (residue number reindexed from 1) H40 D90 Q180 G181 D182 S183 G184
Enzyme Commision number 3.4.21.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide C S26 W29 P120 C122 V206 A207 I242 R243 S11 W14 P112 C114 V194 A195 I227 R228
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
Biological Process
GO:0006508 proteolysis

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:2wub, PDBe:2wub, PDBj:2wub
PDBsum2wub
PubMed20004165
UniProtQ04756|HGFA_HUMAN Hepatocyte growth factor activator (Gene Name=HGFAC)

[Back to BioLiP]