Structure of PDB 2wd9 Chain C

Receptor sequence
>2wd9C (length=536) Species: 9606 (Homo sapiens) [Search protein sequence]
QWGHQEVPAKFNFASDVLDHWADMEKAGKRPPSPALWWVNGKGKELMWNF
RELSENSQQAANVLSGACGLQRGDRVAVVLPRVPEWWLVILGCIRAGLIF
MPGTIQMKSTDILYRLQMSKAKAIVAGDEVIQEVDTVASECPSLRIKLLV
SEKSCDGWLNFKKLLNEASTTHHCVETGSQEASAIYFTSGTSGLPKMAEH
SYSSLGLKAKMDAGWTGLQASDIMWTISDTGWILNILCSLMEPWALGACT
FVHLLPKFDPLVILKTLSSYPIKSMMGAPIVYRMLLQQDLSSYKFPHLQN
CVTVGESLLPETLENWRAQTGLDIRESYGQTETGLTCMVSKTMKIKPGYM
GTAASCYDVQIIDDKGNVLPPGTEGDIGIRVKPIRPIGIFSGYVDNPDKT
AANIRGDFWLLGDRGIKDEDGYFQFMGRADDIINSSGYRIGPSEVENALM
EHPAVVETAVISSPDPVRGEVVKAFVVLASQFLSHDPEQLTKELQQHVKS
VTAPYKYPRKIEFVLNLPKTVTGKIQRAKLRDKEWK
3D structure
PDB2wd9 Structural Snapshots for the Conformation- Dependent Catalysis by Human Medium-Chain Acyl- Coenzyme a Synthetase Acsm2A.
ChainC
Resolution2.6 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) T221 T364 E365 N467 R472 K557
Catalytic site (residue number reindexed from 1) T188 T331 E332 N434 R439 K524
Enzyme Commision number 6.2.1.2: medium-chain acyl-CoA ligase.
6.2.1.25: benzoate--CoA ligase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MG C M483 V488 M450 V455
BS02 IBP C W265 I266 G362 Q363 T364 R472 W232 I233 G329 Q330 T331 R439
Gene Ontology
Molecular Function
GO:0004321 fatty-acyl-CoA synthase activity
GO:0005524 ATP binding
GO:0015645 fatty acid ligase activity
GO:0016874 ligase activity
GO:0018858 benzoate-CoA ligase activity
GO:0031956 medium-chain fatty acid-CoA ligase activity
GO:0046872 metal ion binding
GO:0102391 decanoate-CoA ligase activity
Biological Process
GO:0006631 fatty acid metabolic process
GO:0006633 fatty acid biosynthetic process
GO:0006637 acyl-CoA metabolic process
GO:0036112 medium-chain fatty-acyl-CoA metabolic process
GO:0042593 glucose homeostasis
GO:0070328 triglyceride homeostasis
Cellular Component
GO:0005739 mitochondrion
GO:0005759 mitochondrial matrix

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:2wd9, PDBe:2wd9, PDBj:2wd9
PDBsum2wd9
PubMed19345228
UniProtQ08AH3|ACS2A_HUMAN Acyl-coenzyme A synthetase ACSM2A, mitochondrial (Gene Name=ACSM2A)

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