Structure of PDB 2w3s Chain C

Receptor sequence

>2w3sC (length=450) Species: 1061 (Rhodobacter capsulatus)

MEIAFLLNGETRRVRIEDPTQSLLEWLRAEGLTGTKEGCNEGDCGACTVM
IRDAAGSRAVNACLMMLPQIAGKALRTIEGIAAPDGRLHPVQQAMIDHHG
SQCGFCTPGFIVSMAAAHDRDRKDYDDLLAGNLCRCTGYAPILRAAEAAA
GEPPADWLQADAAFTLPAFLPETSDALADWYLAHPEATLIAGGTDVSLWV
TKALRDLPEVAFLSHCKDLAQIRETPDGYGIGAGVTIAALRAFAEGPHPA
LAGLLRRFASEQVRQVATIGGNIANGSPIGDGPPALIAMGASLTLRRGQE
RRRMPLEDFFLEYRKQDRRPGEFVESVTLPKSAPGLRCYKLSKRFDQDIS
AVCGCLNLTLKGSKIETARIAFGGMAGVPKRAAAFEAALIGQDFREDTIA
AALPLLAQDFTPLSDMRASAAYRMNAAQAMALRYVRELSGEAVAVLEVMP

3D structure

• PDB: 2w3s Mechanism of Substrate and Inhibitor Binding of Rhodobacter Capsulatus Xanthine Dehydrogenase.
• Chain: C
• Resolution: 2.6 Å

Enzymatic activity

• Enzyme Commision number: 1.1.1.204: Transferred entry: 1.17.1.4.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	FES	C	C103 C106 C134 C136	C103 C106 C134 C136
BS02	FES	C	G38 C39 N40 G42 C44 G45 C47 C63	G38 C39 N40 G42 C44 G45 C47 C63
BS03	FAD	C	G42 L201 A203 G204 G205 T206 D207 V208 W211 F270 A271 A279 T280 G283 N284 A286 G292 D293 R330 F335 V336	G42 L189 A191 G192 G193 T194 D195 V196 W199 F258 A259 A267 T268 G271 N272 A274 G280 D281 R318 F323 V324

Gene Ontology

Molecular Function

• GO:0000166 nucleotide binding
• GO:0004854 xanthine dehydrogenase activity
• GO:0005506 iron ion binding
• GO:0016491 oxidoreductase activity
• GO:0046872 metal ion binding
• GO:0050660 flavin adenine dinucleotide binding
• GO:0051536 iron-sulfur cluster binding
• GO:0051537 2 iron, 2 sulfur cluster binding
• GO:0071949 FAD binding

External links

• PDB: RCSB:2w3s, PDBe:2w3s, PDBj:2w3s
• PDBsum: 2w3s
• PubMed: 19109249
• UniProt: O54050