Structure of PDB 2v16 Chain C

Receptor sequence
>2v16C (length=333) Species: 9606 (Homo sapiens) [Search protein sequence]
GNTTSSVILTNYMDTQYYGEIGIGTPPQTFKVVFDTGSSNVWVPSSKCSR
LYTACVYHKLFDASDSSSYKHNGTELTLRYSTGTVSGFLSQDIITVGGIT
VTQMFGEVTEMPALPFMLAEFDGVVGMGFIEQAIGRVTPIFDNIISQGVL
KEDVFSFYYNRDSSLGGQIVLGGSDPQHYEGNFHYINLIKTGVWQIQMKG
VSVGSSTLLCEDGCLALVDTGASYISGSTSSIEKLMEALGAKKRLFDYVV
KCNEGPTLPDISFHLGGKEYTLTSADYVFQESYSSKKLCTLAIHAMDIPP
PTGPTWALGATFIRKFYTEFDRRNNRIGFALAR
3D structure
PDB2v16 Structure-Based Drug Design: The Discovery of Novel Nonpeptide Orally Active Inhibitors of Human Renin
ChainC
Resolution2.8 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.4.23.15: renin.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 C47 C T12 Q13 D32 G34 S35 R74 Y75 S76 P111 A115 F117 D215 G217 A218 S219 T15 Q16 D35 G37 S38 R79 Y80 S81 P115 A119 F121 D219 G221 A222 S223 PDBbind-CN: -logKd/Ki=8.22,IC50=6nM
BindingDB: IC50=0.8nM
Gene Ontology
Molecular Function
GO:0004190 aspartic-type endopeptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:2v16, PDBe:2v16, PDBj:2v16
PDBsum2v16
PubMed10903938
UniProtP00797|RENI_HUMAN Renin (Gene Name=REN)

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