Structure of PDB 2v12 Chain C

Receptor sequence
>2v12C (length=333) Species: 9606 (Homo sapiens) [Search protein sequence]
GNTTSSVILTNYMDTQYYGEIGIGTPPQTFKVVFDTGSSNVWVPSSKCSR
LYTACVYHKLFDASDSSSYKHNGTELTLRYSTGTVSGFLSQDIITVGGIT
VTQMFGEVTEMPALPFMLAEFDGVVGMGFIEQAIGRVTPIFDNIISQGVL
KEDVFSFYYNRDSSLGGQIVLGGSDPQHYEGNFHYINLIKTGVWQIQMKG
VSVGSSTLLCEDGCLALVDTGASYISGSTSSIEKLMEALGAKKRLFDYVV
KCNEGPTLPDISFHLGGKEYTLTSADYVFQESYSSKKLCTLAIHAMDIPP
PTGPTWALGATFIRKFYTEFDRRNNRIGFALAR
3D structure
PDB2v12 Structure-Based Drug Design: The Discovery of Novel Nonpeptide Orally Active Inhibitors of Human Renin
ChainC
Resolution3.2 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.4.23.15: renin.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 C39 C T18 Y20 D38 G40 S41 Y83 T85 A122 F124 D226 G228 A229 T15 Y17 D35 G37 S38 Y80 T82 A119 F121 D219 G221 A222 PDBbind-CN: -logKd/Ki=9.05,IC50=0.9nM
BindingDB: IC50=0.9nM
Gene Ontology
Molecular Function
GO:0004190 aspartic-type endopeptidase activity
Biological Process
GO:0006508 proteolysis

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:2v12, PDBe:2v12, PDBj:2v12
PDBsum2v12
PubMed10903938
UniProtP00797|RENI_HUMAN Renin (Gene Name=REN)

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